Synthesis of 2-phenyl pyridine derivatives from aryl ketones and 1,3-diaminopropane using palladium acetate as a catalyst

Abstract

A simple and efficient method for the synthesis of 2-phenyl pyridine via cyclization of aryl ketone with 1,3-diaminopropane using palladium acetate is established. This method is mild, operationally simple, involves short reaction time and involves easy workup procedure to afford the corresponding 2-phenyl pyridines in moderate to good yield.