Synthesis of 2-oxo-2,3,5,6-tetrahydro-5-thioxoimidazo[1,2- c]quinazolines by one-pot cyclization of α-aminocarboxylic esters with 2-(isothiocyanato)benzonitrile (ITCB)

Anja Bodtke,Helmut Reinke,Dirk Michalik,Peter Langer

doi:10.1016/j.tet.2006.05.075

Synthesis of 2-oxo-2,3,5,6-tetrahydro-5-thioxoimidazo[1,2- c]quinazolines by one-pot cyclization of α-aminocarboxylic esters with 2-(isothiocyanato)benzonitrile (ITCB)

Anja Bodtke, Helmut Reinke + Show 2 more

https://doi.org/10.1016/j.tet.2006.05.075

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Journal: Tetrahedron	Publication Date: Jun 19, 2006
Citations: 5

Affiliation: University of Greifswald, University of Rostock, Leibniz Institute for Catalysis

#Cyclization Of Esters #One-pot Cyclization

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Abstract

The cyclization of 2-(isothiocyanato)benzonitrile with α-aminocarboxylic esters and acids afforded a variety of 2-oxo-2,3,5,6-tetrahydro-5-thioxo-imidazo[1,2- c]quinazolines with very good regioselectivity.

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