Abstract
Reported is a simple and efficient strategy for the one-step synthesis of 2-heteroquinazolin-4-(3H)-ones 3 involving palladium-catalyzed intermolecular nucleophile 2 addition to carbodiimide 1 followed by an intramolecular cyclocarbonylation reaction. After optimization of the reaction conditions, it was demonstrated that the reaction system is not sensitive to solvent and pressure of CO. The scope of this reaction was extended to a variety of carbodiimides (with EDGs and EWGs) and nucleophiles (cyclic and acyclic secondary amines, secondary anilines, phenols) to afford products 3 in moderate to good yields. However, thiol nucleophiles were found not to participate in the reaction. A plausible mechanism was proposed without evidence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
