Abstract
Synthesis of di‐ and tri‐substituted fluoroalkylated azepanes was achieved by ring expansion of pyrrolidines via a regioselective attack of nucleophiles on a bicyclic azetidinium intermediate. A broad scope of azepanes, substituted at C4 and bearing a α‐trifluoromethyl, α‐difluoromethyl or α‐perfluorobutyl group, can be synthesized by this method by using a wide variety of nucleophiles.
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