Synthesis of 2‐Aryl‐1,2,3‐triazoles by Oxidative Cyclization of 2‐(Arylazo)ethene‐1,1‐diamines: A One‐Pot Approach

Abstract

AbstractA one‐pot approach for the synthesis of 2‐aryl‐5‐amino‐1,2,3‐triazoles is reported. This approach involves a tandem nucleophilic addition of alkylamines to hydrazonoyl cyanides and in situ oxidative cyclization of the resulting 2‐(arylazo)ethene‐1,1‐diamines in the presence of copper(II) acetate and air. The described one‐pot procedure is characterized by good yields, excellent selectivity, methodical simplicity, and uses readily available chemicals. This method was applied to the gram‐scale synthesis of 2‐aryl‐1,2,3‐triazoles.