Abstract
Abstract Alkynylation reaction of 2,2-difluoro-1-iodoethenyl p-toluenesulfonate 1 with alkynyltributylstannanes in the presence of 10 mol% Pd(PPh3)4 and 10 mol% CuI in THF at reflux temperature for 3 h provided the corresponding 1,1-difluoro-1,3-enynyl tosylates 2 in 65–85% yields. The further arylation reaction of 2 with aryltributylstannanes in the presence of 10 mol% Pd(PPh3)2Cl2 and 3 equiv. of LiBr in THF at reflux temperature for 8 h afforded the coupled products 3 in 32–83% yields.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
