Abstract
The synthesis of 9-(ß-D-ribofuranosyl)-2-amino-6-acetamidomethyl -purine (5) is described by displacement of the 6-chloro substituent of 9 -(2,3.5-tri-O-acetyl-ß-D-ribofuranosyl)-2-amino-6-chloropurine by a cyano group (tetraethylammonium cyanide in the presence of trimethylamine) and subsequent catalytic reduction. Acylation with acetic anhydride in pyridine methanol afforded the tetra-acetyl derivative 4, from which the ester function could be removed selectively with ease.
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