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Abstract
A variety of 2-Amino-5-substituted -1,3,4-thiadiazoles (ATDA) were prepared by the reaction of thiosemicarbazide with different substituted carboxylic acids and phosphorous oxychloride as catalyst using conventional methods in comparison with the advantages of microwave techniques. The 5-(substituted-1,3,4-thiadiazol-2-yl) carbamates derivatives were prepared by refluxing these (ATDA) with ethyl chloroformates using pyridine as a base to neutralize the acid produced which gave higher yield than sodium carbonate. The structures of the products were supported by IR spectroscopy.
Highlights
Several procedures were reported for the synthesis of 2-aminothiadiazoles, in many of these methods a thiosemicarbazide was the starting material
As part of continuous program directed toward the studies with polyfunctionally substituted heterocycles (AL-Gwady et al, 2007), it was become of interest to investigate preparative routs to synthesize anticipated insecticidal active carbamate derivatives by the reactions of chloroformate with a variety of some 2-amino-5-substituted -1,3,4thiadiazoles (ATDA)
These (ATDA) were synthesized by the reaction of thiosemicarbazide and substituted carboxylic acids using microwave irradiation with comparison with conventional method in which phosphorous oxychloride was used as catalyst
Summary
Several procedures were reported for the synthesis of 2-aminothiadiazoles, in many of these methods a thiosemicarbazide was the starting material. These (ATDA) were synthesized by the reaction of thiosemicarbazide and substituted carboxylic acids using microwave irradiation with comparison with conventional method in which phosphorous oxychloride was used as catalyst.
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