Synthesis of 2‐amino‐4H‐chromenes and spirochromenes using basic ionic liquid, 2‐hydroxyethylammonium formate as green, stable, and reusable catalyst

Abstract

AbstractIn this study, a number of 2‐amino‐4H‐chromenes and spirochromenes were fabricated in a one‐pot three‐component synthesis manner from commercially available chemicals including phloroglucinol, malononitrile, and aldehydes/isatines with acceptable and easy efficiencies. This methodology was performed in the presence of 2‐hydroxyethylammonium formate as an effective and reusable ionic liquid catalyst. Water was selected as the reaction medium and the reaction was carried out at ambient temperature to create an environmentally friendly route. Other salient features of this method include catalyst chemical stability, good yields, short reaction times, and a simple work‐up procedure.