Abstract
A series of 2, 6-Diaryl-4-5-Secondary aminonicotinonitriles derivatives were synthesized by the reaction of 2H- pyran-2-one (I) and the N-aryl amidine (II) using KOH as catalyst in DMF at room temperature. All synthesized compounds (IIIa-i) evaluated for antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Proteus vulgaris, Aspergillus niger and, Candida albicans strains most of the compound shows potent activity.
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