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Abstract
A series of rhodanine derivatives were synthesized by Knoevenagel condensation. All the synthesized compounds were tested for their in vitro anticancer activity against MCF-7 and BT-474 human breast cancer cell lines. All the synthesized compounds were characterized and screened for their antimicrobial activity against bacterial and fungal strain. Majority of the compounds showed good to moderate anticancer and antimicrobial activity. Among these compounds one showed promising activity against gram-positive bacteria B. subtilis and S. aureus when compared with ampicillin. Some of the most potent compounds possessed selective antimicrobial activity.
Highlights
The dealing of microbial infections remains a very challenging salutary problem because of emerging infectious diseases and the increasing number of multidrugresistant microbial pathogens
All the synthesized compounds were screened for their anticancer activity against cell line MCF-7
The results suggest that the compounds could be exploited as an antimicrobial agent
Summary
The dealing of microbial infections remains a very challenging salutary problem because of emerging infectious diseases and the increasing number of multidrugresistant microbial pathogens. Because of the facts mentioned above, Rhodanine derivatives were synthesized, characterized by different spectral analysis techniques and screened for their antimicrobial activity. All the synthesized compounds were screened for their anticancer activity against cell line MCF-7. The results suggest that the compounds could be exploited as an antimicrobial agent. The Rhodanine derivatives have been known for over five decades, and there are various reports available on Rhodanine derivatives as antimicrobial agents.. The Rhodanine derivatives have been known for over five decades, and there are various reports available on Rhodanine derivatives as antimicrobial agents.19-24 These reports suggested that Rhodanine nuclei were essential to the observed levels of antimicrobial activity.. We make a plan to synthesized Rhodanine derivatives as an antimicrobial agent by preparing hybrid molecules having similar features of reported potent antimicrobial agents (Figure 1)
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