Abstract
2,4,5-Trisubstituted imidazoles have been synthesized by treatment of benzil with aldehydes and ammonium acetate in water under reflux in the presence of p-dodecylbenzenesulfonic acid as catalyst. The same reaction using an additional amine affords 1,2,4,5-tetrasubstituted imidazoles. The products are formed in high yields within 4 h under eco-friendly conditions.
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