Synthesis of 2,3‐disubstituted Benzofuran via HNTf2/TMSOTf Catalyzed Intermolecular Reaction of o‐alkenyl phenols and Aldehydes

Abstract

AbstractThe synthetic methods of 2,3‐disubstituted benzofurans have been widely studied, however, the maneuvers of using o‐alkenyl phenols as starting materials are less explored. Herein, we report a general and efficient strategy via HNTf2/TMSOTf catalyzed cascade reaction with readily available o‐alkenyl phenols and aldehydes as starting materials, which provides 2,3‐disubstituted benzofuran derivatives in moderate to good yields. This method features metal‐free circumstances, broad substrate scope, mild reaction conditions, and easy scale preparation.magnified image