Abstract
AbstractAn efficient, mild and environmentally benign method has been developed for the synthesis of 2,3‐dihydroflavonecoumarins. The reaction of 2‐hydroxyacetophenones 2 with 4‐formylcoumarin 3 using anhydrous potassium carbonate as a mild base. All the synthesized compounds were evaluated for their antifungal activity against Candida albicans, Aspergillus flavus and Aspergillus niger fungal strains by broth dilution method. The tested compounds have exhibited promising in vitro potency with low MIC values rangs from 0.4 to 3.12 μg/mL. The in vitro anti‐inflammatory potency of synthesized compounds by gelatin zymography is comparable to tetracycline and is found to be excellent against Matrix metalloproteinase (MMP‐2). Molecular docking study was performed for all the synthesized compounds with binding site of Cytochrome P450 14 alpha‐sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with fluconazole PDB (1EA1) and results obtained are quite promising.
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