Abstract
Direct fluorination of m-tyrosine, m-tyramine and 3-hydroxyphenyl acetic acid with [ 18F]F 2 in anhydrous hydrogen fluoride produced in each case a mixture of 2- and 6-fluoro derivatives as the major products. The radiochemical yields with respect to [ 18F]F 2 of each reaction was 43, 30 and 37%, respectively. The radiofluorination of m-tyrosine in HF was more efficient than in CH 3CN/BF 3, TFA or HF/BF 3. From 100 mCi of [ 18F]F 2, 16 mCi of a mixture of 2- and 6- fluoro- L-m- tyrosine (specific activity 200 mCi/mmol) was produced at the end of 150 min of synthesis time.
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