Abstract
AbstractIsobutyl [3‐14C] cyanoacrylate and diethyl [3‐14C] methylidenemalonate were synthesized by the intermediate of their protective Diels‐Alder adduct with anthracene. These adducts (2a‐b) were obtained in a one‐pot procedure by Knoevenagel condensation of [14C] paraformaldehyde with isobutyl cyanoacetate and diethyl malonate respectively in the presence of a basic catalyst and anthracene. The adducts are stable crystalline compounds easily purified by recrystallization. The olefinic target coumpounds (1a‐b) were obtained in high chemical and radiochemical purity (>99%) by thermolysis at 220 °C in mineral oil in the presence of maleic anhydride.
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