Abstract
The optimal conditions for the synthesis of 11C-labeled SCH 23390 by radio-methylation of its desmethyl precursor, SCH 24518, with [ 11C]iodomethane are described. Isocratic reversed phase HPLC was used for the purification of [ 11C]SCH 23390. The specific activity range in 30 runs was 10–235 Ci/mmol and average radiochemical yield was 72% based on [ 11C]iodomethane. Mean synthesis time was 40–60 min from the end of bombardment. Preliminary animal studies indicate that [ 11C]SCH 23390 would be useful in visualizing D1 receptors in a living brain by positron tomography.
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Schedule a callMore From: International Journal of Radiation Applications & Instrumentation. Part A, Applied Radiation & Isotopes
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