Abstract

Abstract[11C]‐acetone, prepared from 11CO2 and methyllithium, was reduced to [11C]‐isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]‐sarin.3.4 GBq (100 mCi) of [11C]‐sarin may be obtained from about 55.5 GBq (1.5 Ci) of 11CO2 in 40 minutes. The product purified by HPLC, is obtained with a specific radioactivity ranging from 22.2 to 33.3 GBq (600 to 900 mCi/μmol.).

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