Abstract
AbstractA method for labelling acamprosate (calcium N‐acetyl homotaurinate), an anti‐craving compound for ethanol, with 11C, has been developed for in vivo studies with positron emission tomography (PET). The synthesis was based on the acylation of homotaurinate using [11C]acetyl chloride as the labelling agent. Reversed‐phase HPLC in highly aqueous mobile phase conditions was used for product purification. The radiochemical yield achieved was about 1.14 GBq (31 mCi) with a specific radioactivity of 8.14 GBq/µmol (220 mCi/µmol). For the identification of 11C‐radioactivity and determination of specific radioactivities, HPLC and 1H‐NMR were used. Copyright © 2001 John Wiley & Sons, Ltd.
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