Abstract
AbstractTin mesoporphyrin IX dichloride (Sn‐MPCl2) is a heme oxygenase inhibitor of current clinical interest for the treatment of neonatal hyperbilirubinemia. The synthesis of [119mSn]‐MPCl2 for drug metabolism and disposition studies is reported. [119mSn]‐MPCl2 was prepared in 60% radiochemical yield by metalation of the porphyrin nucleus of mesoporphyrin IX dihydrochloride with tin(II)‐119m acetate. The product had a specific activity of 43.4 mCi/mmol and a radiochemical purity of 99%, as determined by radio‐HPLC analysis.
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