Abstract
[1-11C]-2-Octynoic acid, [1-11C)-2-decynoic acid and 1-11C]-3-(R,S)-methyloctanoic acid have been synthesized in order to evaluate these compounds as PET (Positron Emission Tomography) tracers for imaging in vivo medium-chain acyl-CoA dehydrogenase and medium-chain fatty acid utilization. The synthesis was performed by the Grignard reaction between alkylmagnesium bromides and [11C]CO2. The radiochemical yields of [1-11C]-2-octynoic acid, [1-11C]-2-decynoic acid, and [1-11C]-3-(R,S)-methyloctanoic acid were 10, 7 and 1% based on the [11C]CO2 used, respectively. Radiochemical purity was >99% in all cases. © 1997 John Wiley & Sons, Ltd.
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