Abstract
A synthesis of 11-(piperazin-1yl)-5 H-dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.
Highlights
Dibenzodiazepine derivatives have attracted much attention from the medicinal chemistry community owing to their potential use in the treatment of psychiatric disorders
In past years large number of derivatives from this class have been synthesized and tested for their pharmacological actions like muscarinic agonistic and dopamine antagonistic activities1-7. 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is a structural analogue of clozapine, an important atypical antipsychotic
We report a simple and high yielding method for kilo scale synthesis of 11(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Summary
Dibenzodiazepine derivatives have attracted much attention from the medicinal chemistry community owing to their potential use in the treatment of psychiatric disorders. Abstract: A synthesis of 11-(piperazin-1yl)-5H-dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. The drugs in current clinical use from this class are few in number.
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