Abstract
This review describes methods for the synthesis of 1-trifluomethylindanes and close structures, which are still quite rare and scarcely available compounds. There are two main approaches to obtain 1-CF3-indanes. The first one is the construction of an indane system from CF3 precursors; the main methods are acid-mediated Friedel–Crafts cyclization, transition metal-catalyzed [3+2] annulation, and free-radical transformations. The second approach is the trifluoromethylation of a ready-made indane core by various CF3 sources, such as Ruppert–Prakash or Togni reagents. Many of these synthetic procedures possess high regio- and stereo-selectivity, allowing the preparation of unique 1-CF3-indane structures. In recent years, great attention has been paid to the synthesis of 1-CF3-indanes, due to the discovery of important biologically active properties for these compounds.
Highlights
Organofluorine compounds are widely used and are of great importance in chemistry, biology, medicine, agriculture, materials science, and other fields of science and technology.The presence of fluorine atoms in organic molecules significantly changes their chemical, physical, and pharmokinetic properties
The second approach is the trifluoromethylation of a ready-made indane core by various CF3 sources, such as Ruppert–Prakash or Togni reagents
The development of novel methods of synthesis of CF3 -indane derivatives and investigation of their biologically active properties is an important goal for chemistry, biology, and medicine
Summary
Organofluorine compounds are widely used and are of great importance in chemistry, biology, medicine, agriculture, materials science, and other fields of science and technology. The development of novel methods of synthesis of CF3 -indane derivatives and investigation of their biologically active properties is an important goal for chemistry, biology, and medicine. These fluorinated derivatives must find broad application in material science and many other fields. F1-trifluoromethyl indanes are extremely promising objects for medicinal chemOMe. μM vestigation of their biologically properties is an important goal for chemistry, biolMeO ogy, and medicine. ΜM vestigation of their biologically properties is an important goal for chemistry, biolMeO ogy, and medicine Cl indanones to show the main approaches to the preparation of these compounds
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