Synthesis of 1-substituted Tetrazoles Using CoFe2O4 Nanoparticles as a Magnetically Recoverable and Reusable Catalyst

Abstract

Nano CoFe2O4 is found to be efficient catalyst for synthesis of 1-substituted 1H-1,2,3,4-tetrazoles under solvent- free conditions. The significant advantages of this methodology are high yields, elimination of dangerous and harmful hydrazoic acid and simple work-up procedure. The catalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused with no significant loss in its reactivity. Keywords: CoFe2O4 Nanoparticles, Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole.