Synthesis of 1-germatranol and its C-substituted derivatives

Abstract

1. A method is proposed for the preparation of 1-germatranols with the general formula (R=Me, Ph, n=0-3, m=0.1) by the reaction of germanium dioxide with tris(2-hydroxyalkyl)amines by heating in an aqueous medium. 2. For the first time, C-substituted 1-germatranols (R=Me, n=1, m=1; R=Me, n=2–3, m=0; R=Ph, n=1, m=0) were obtained and characterized.