Abstract
: In the current work, we have utilized the reactivity of N-(4- acetylphenyl)-2-(4-formylphenoxy)acetamide for the synthesis of novel series of 1,2- dihydropyridines, Arylidenes, and hydrazides. Our strategies were prolonged for the synthesis of novel terthienylnicotinamidine hydrochloride salt through a Stille coupling reaction of 6-(5'-bromo-[2,2'-bithiophen]-5-yl)nicotinonitrile with 2-tributyltin thiophene followed by treatment with lithium trimethylsilylamide and subsequent hydrolysis. : The newly prepared structures were well-elucidated by analytical and spectral data (IR, 1H-NMR, 13C-NMR, MS, and elemental analysis). The theoretical studies of terthienylnicotinamidine verified that the other atoms that carry a high density of positive values are considered active centers for the electron acceptor. : The novel synthesized compounds were efficiently established by spectroscopic data and elemental analysis. The antioxidant activity of the synthesized arylidene, hydrazide, and dihydropyridine compounds was assessed by ABTS•+ free radical assay. : The results verified that the transformation of N-(4-acetylphenyl)-2-(4-formylphenoxy)acetamide (47.6%) into hydrazide analogs provided remarkable antioxidant activity (78.1, and 60.3%).
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