Abstract
A twist in the Ugi four-component reaction: The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-Å molecular sieves afforded α-ketoamides in moderate to good yields (see scheme). In contrast, 3-Å molecular sieves did not promote the desired multicomponent reaction. R1=alkyl; R2=alkyl, aryl.
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