Synthesis of α-enamino esters via Cu(ii)-promoted dehydrogenation of α-amino acid esters: application to the synthesis of polysubstituted pyrroles

Abstract

α-Enamino esters are synthesized from α-amino acid esters using Cu(ii)-promoted dehydrogenation. Application of the α-enamino esters to the synthesis of polysubstituted pyrroles is achieved through oxidative coupling with alkynes under Cu(ii)-promoted conditions.