Abstract
Pyridines and 2,2'-bipyridines have been employed as useful ligands in molecular recognition chemistries. Halomethyl-substituted bipyridine or oligopyridine derivatives were required for the assembly of bipyridine or oligopyridine units with a supporting mother functional part in artificial biofunctional molecules. A series of ω-(bromomethyl)bipyridines and related ω-(bromomethyl)-pyridinoheteroaromatic compounds (types I-III) were synthesized in this paper. Preparation of oligopyridines and pyridinoheteroaromatic compounds have been carried out by either intermolecular ligand coupling of alkyl heteroaryl sulfoxide with pyridyllithium or intramolecular ligand coupling of pyridyl heteroaryl sulfoxide with methylmagnesium bromide for the type I compounds. The type II and III compounds were synthesized by addition of pyridyllithium to pyridinecarboxaldehyde. The ω-bromo groip was introduces by radical bromination reaction of methylpyridyl group using NBS and BPO (dibenzoyl peroxide) or bromination of ω-(hydroxymethyl)pyridine using a combination of CBr 4 and Ph 3 P
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