Synthesis of α,α-difluoro-β-amino carbonyl-containing sulfonamides and related compounds

Abstract

Mannich addition reactions between in situ generated α,α-difluoroenolates and various N-sulfonyl imines readily occur with exceptionally high reaction rates at ambient temperature. The method features remarkable generality and enjoys operationally convenient conditions underscoring its practicality and methodological importance for preparation of sulfonamides bearing β-amino-α,α-difluoro ketone moiety.