SYNTHESIS, MOLECULAR STRUCTURE AND TUMOR-INHIBITING PROPERTIES OF NICKEL(II) AND COBALT(II) COMPLEXES OF 2,2′-DIAMINO-4,4′-BITHIAZOLE. CRYSTAL STRUCTURE OF [NIL2(SO4)(MEOH)] · 3MEOH

Abstract

Complexes of Ni(II) and Co(II) with 2,2′-diamino-4,4′-bithiazole (L) formulated as ML2(SO4)· XMeOH (X=0 or 4), were synthesized and characterized by elemental analysis, conductivity measurement, 1H NMR, IR and electronic spectra. The structure of [NiL2(SO4)(MeOH)] · SMeOH has been determined by single-crystal X-ray methods. The nickel atom is octahedrally coordinated by two chelating organic ligands and two oxygen atoms of SO4 and MeOH in a cis arrangement. Ni‒N bond lengths range from 2.076 to 2.100 Å; Ni‒O(SO4) is 2.118 Å and Ni‒O(MeOH) is 2.128 Å. The effect of these complexes on DNA synthesis in Sarcoma 180 tumor cells has been investigated by the technique of isotopic liquid scintillation. Results indicate that the complexes inhibit DNA synthesis in the tumor cells.