Synthesis, molecular structure and biological activity of novel bis-1,3-tropolones based on 4-chloro-2,7-dimethyl-1,8-naphthyridine

Abstract

The acid-catalyzed reaction of 4-chloro-2,7-dimethyl- 1,8-naphthyridine with 4,6-di-tert-butyl-3-nitro-1,2-benzoquinone leads to new bis-1,3-tropolones. The crystal structures of the obtained bis-1,3-tropolones were determined by X-ray diffraction analysis; the spectral and luminescent properties, the structural and energy characteristics of the compounds were examined. The cytotoxic effect in vitro against cancer cell lines A549, H1299, HT29, CT26 and B16F10 was assessed using MTT assay.