Abstract
A new series of 2-(substituted benzylidene)-1-(quinoline-4-yl)hydrazine was designed, synthesized, and evaluated for their antimicrobial activity. A molecular docking study was performed against bacterial topoisomerase II (PDB code: 2XCT) using MOE 2012.10 and Leadit 2.1.2 softwares. Compound 4a with the highest antibacterial activity was labeled with one of the most important radioactive isotopes (technetium-99m). 99m Tc–4a complex showed high labeling yield, stability, and uptake in the inflamed tissue (T/NT = 6.11 ± 0.5) compared to the commercially available 99mTc-ciprofloxacin (T/NT = 3.6 ± 0.4).
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