Synthesis, identification and in vitro drug release of layered zinc hydroxide-gemifloxacin nanohybrids

Abstract

The intercalation of fluoroquinolone antibiotic, Gemifloxacin (GEM) anions, into layered zinc hydroxide (LZH) has been achieved by using ion-exchange method. The GEM-LZH/Chitosan nanocomposite coating Chitosan nanocomposite was prepared in alkaline aqueous solution. Powder X-ray diffraction studies confirmed a basal spacing of 25.54 A, showing that the GEM was successfully intercalated into the LZH interlayer. The arrangement of GEM anions was in a monolayer form between the LZH interlayers. Fourier transform infrared spectroscopy results exhibited the formation of the host–guest nanohybrid without any change in the structure of the GEM. The increased thermal stability of nanohybrid was confirmed by thermal analyses. The in vitro release study of GEM from nanohybrid and nanocomposite was investigated in phosphate buffer saline solution of pH 4.8 and 7.4 using ultraviolet–Visible spectroscopy.