Abstract

An optically active macrocyclic diesterdihydrazide with 2,6-pyridinedicarboxylic and adipic acid moieties was synthesized efficiently from available (–)-α-pinene through an intermediate hydroxyketone [1R-(1′-hydroxyethyl)-3R-(2″-hydroxyethyl)-2,2-dimethylcyclobutane) using successive [2 + 1]-reaction of the last with 2,6-pyridinedicarboxylic acid dichloride and [1 + 1]-condensation of the resulting diketodiester with adipic acid dihydrazide.

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