Synthesis et activites biologiques de certains derives thyroxiniens et adrenergiques—VII Influence de divers derives phenoliques iodes sur la monoamine oxydase hepatique de cobaye et sur la monoamine oxydase cerebrale de rat

Abstract

The action on hepatic and cerebral monoamine oxidase of several iodinated phenols derivated from 3:5-diiodotyramine and thyroid hormones and some of their structural analogues was studied. The enzymatic activity was tested by a variety of methods and in addition a new technique was developed using polarographic measurement of dissolved oxygen. Iproniazid was used as standard inhibitor. 3:5-Diiodotyramine is a potent inhibitor of guinea-pig liver MAO but no effect was obtained on rat cerebral MAO. Iodothyroacetic acids [3:5-diiodothyroacetic acid (TA 2) and 3:5:3′-triiodothyroacetic acid (TA 3)] and 3:5-diidothyroadrenaline- (TAd 2) were inhibitors of both liver and cerebral MAO. L-thyroxine (T 4) and 3:5:3′- triiodo- L- thyronine (T 3) no activity on liver MAO, whereas triiodothyronine has a relative effect on the cerebral enzyme.