Abstract
Abstract Two potentially N6O2 macroacyclic Schiff base ligands (H2L1 and H2L2) were derived from the condensation of a new polyamine, 2,2′-(4,4′-(propane-1,3-diyl)bis(piperazine-4,1-diyl))diethanamine (A), with 2-Hydroxy- benzaldehyde or 2-hydroxy-3-methoxybenzaldhyde respectively. In the presence of appropriate metal ions, six manganese (II), zinc (II) and cadmium (II) macroacyclic Schiff-base complexes were obtained. All products were characterized by elemental analysis, mass spectrometry and FT-IR, 1H and 13C NMR. Competitive 7Li NMR measurements were employed to monitor the stability of Cd2+, Zn2+ and Mn2+ ions complexes with H2L1 and H2L2 Ligands in methanol and acetonitrile separately. The variation of 7Li chemical shift with [H2L]/[M2+] mole ratios indicated the formation of 1:1 complexes. The formation constants of the resulting complexes were found to be in the order M2+-H2L1 > M2+-H2L2 and Cd2+-H2L > Zn2+-H2L > Mn2+-H2L. The resulting complexes are more stable in acetonitrile than in methanol. The cytotoxic properties of complexes were studied.
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