Abstract
[Cu(L1)Cl2]∙3H2O (1) and [Cu(L2)Cl]∙2H2O (2) based on new unsymmetrical tripodal ligands (L1 = {(N-methyl-imidazolylmethyl)[N-methyl-N-(N-methyl-imidazolylmethyl)imidazolylmethyl]amino}ethanesulfonic acid, L2 = [bis(2-pyridylmethyl)amino]ethanesulfonic acid) have been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. In the discrete mononuclear structures of 1 and 2, copper is five-coordinate in a distorted trigonal bipyramidal structure. Interaction of the complexes with CT-DNA was investigated by UV–vis spectra, fluorescence spectra, and viscosity; the data reveal that 1 and 2 bind to CT-DNA by partial intercalation. Gel electrophoresis assays demonstrate that these two complexes display efficient oxidative cleavage of supercoiled DNA in the presence of H2O2, and MTT assays indicated that both 1 and 2 showed significant cytotoxicity toward human hepatoma cell HepG-2.
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