Abstract
A new dinuclear copper(II) complex [Cu2(μ-Br)2L2]·0.5MeOH with the benzohydrazone ligand 4-bromo-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL) has been synthesized and characterized by elemental analysis, IR and UV-Vis spectroscopic studies. Single crystal structures of the complex and the benzohydrazone compound were studied. The Cu atoms in the complex are coordinated by two benzohydrazone ligands and two Br bridging groups, forming square pyramidal coordination. The complex has good inhibitory activity on Jack bean urease, with IC50 value of 1.38 μmol·L-1.
Highlights
Urease is a nickel-containing enzyme that catalyzes the rapid hydrolysis of urea to form ammonia.[1]
The benzohydazone compound was facile synthesized by reaction of 2-acetylpyridine and 4-bromobenzohydrazide in methanol
The copper complex was readily prepared by the self-assembly reaction of the benzohydrazone compound with copper bromide in methanol
Summary
Urease (urea amidohydrolase; E.C.3.5.1.5) is a nickel-containing enzyme that catalyzes the rapid hydrolysis of urea to form ammonia.[1]. Hydrazone compounds have been reported to have urease inhibitory activities.[8] Some vanadium complexes with hydrazone ligands show effective biological activities, like antibacterial and urease inhibitory aspects.[9] In the last few years, a number of Schiff bases and their complexes have shown effective urease inhibitory activities.[10] Among the complexes, those with copper atoms are of attention due to their high activities on urease.[11] In continuation of our work,[12] and aiming at obtaining new copper based urease inhibitors, in this work, a new benzohydraone compound 4-bromo-N’-(1-(pyridin-2-yl) ethylidene)benzohydrazide (HL, Scheme 1), and its copper(II) complex, [Cu2(μ-Br)2L2] · 0.5MeOH, are presented
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
