Abstract

A new Cu(II) complex is synthetized by the reaction of copper nitrate and a N-acylhydrazone ligand obtained from the condensation of o-vanillin and 2-thiophecarbohydrazide (H2L). The solid-state structure of [Cu(HL)(H2O)](NO3)·H2O, or CuHL for simplicity, was determined by X-ray diffraction. In the cationic complex, the copper center is in a nearly squared planar environment with the nitrate interacting as a counterion. CuHL was characterized by spectroscopic techniques, including solid-state FTIR, Raman, electron paramagnetic resonance (EPR) and diffuse reflectance and solution UV-Vis electronic spectroscopy. Calculations based on the density functional theory (DFT) assisted the interpretation and assignment of the spectroscopic data. The complex does not show relevant antioxidant activity evaluated by the radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method, being even less active than the free ligand as a radical quencher. Cytotoxicity assays of CuHL against three human tumor cell lines, namely MG-63, A549 and HT-29, revealed an important enhancement of the effectiveness as compared with both the ligand and the free metal ion. Moreover, its cytotoxic effect was remarkably stronger than that of the reference metallodrug cisplatin in all cancer cell lines tested, a promissory result in the search for new metallodrugs of essential transition metals.

Highlights

  • Copper(II) is associated to systems involved in biological processes such as oxygen or electron transport [1]

  • We report the synthesis of a Cu(II) complex obtained by the reaction of and herbicidal activity

  • By means of a straightforward synthetic procedure, crystals of a Cu(II) complex (CuHL), with a hydrazone ligand derived from o-vanillin and a thiophene hydrazide (H2 L), were obtained

Read more

Summary

Introduction

Copper(II) is associated to systems involved in biological processes such as oxygen or electron transport [1]. Copper coordination chemistry has gained importance as many compounds showed interesting chemical and therapeutic properties such as catalytic, analytical, antibacterial, anti-inflammatory and anti-proliferative properties of tumor cells, enhancing the activity of the respective free ligands [5,6,7,8,9,10,11,12]. SBs are a family of compounds characterized by the presence of the azomethine group in their chemical structure. They anti-inflammatory and anti-proliferative properties of tumor cells, enhancing the activity of the respective free ligands [5,6,7,8,9,10,11,12]

Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call