Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobat(II) complex

Abstract

One new binuclear Co(II) complex of N, N, N′, N′-tetrakis(2-benzimidazolylmethyl)-2-hydroxyl-1,3-diaminopropane (H L), [Co 2 L( μ 2- Cl)](ClO 4) 2 · 3CH 3CN · C 2H 5OC 2H 5 ( 1), has been synthesized and its crystal structure and magnetic properties are shown. In 1, each Co(II) atom has a distorted trigonal bipyramidal geometry with a N 3OCl donor set. The central two Co(II) atoms are bridged by one alkoxo-O atom and one Cl atom with the Co1–Co2 separation of 3.239 Å. Susceptibility data of 1 indicate strong intramolecular antiferromagnetic coupling of the high-spin Co(II) atoms. In this paper, the interaction with calf thymus DNA was investigated by UV absorption and fluorescent spectroscopy. Results show the complex binds to ct-DNA with a intercalative mode. The interaction between complex 1 and pBR322 DNA has also been investigated by submarine gel electrophoresis, noticeably, the complex exhibits effective DNA cleavage activity in the absence of any external agents.