Abstract
In the title pyrazoline derivative, C16H16N2O3·H2O, the pyrazoline ring has an envelope conformation with the substituted sp 2 C atom on the flap. The pyrazoline ring makes angles of 86.73 (12) and 13.44 (12)° with the tris-ubstituted and disubstituted benzene rings, respectively. In the crystal structure, the mol-ecules are connected into chains running in the b-axis direction by O-H⋯N hydrogen bonding. Parallel chains inter-act through N-H⋯O hydrogen bonds and π-π stacking of the tris-ubstituted phenyl rings. The major contribution to the surface contacts are H⋯H contacts (44.3%) as concluded from a Hirshfeld surface analysis.
Highlights
Linh Duong Khanh,a* My Hanh Trinh Thi,a Thuy Quynh Bui Thi,a Trung Vu Quoc,a Vuong Nguyen Thienb,c and Luc Van Meerveltd*
The molecules are connected into chains running in the b-axis direction by O— HÁ Á ÁN hydrogen bonding
The major contribution to the surface contacts are HÁ Á ÁH contacts (44.3%) as concluded from a Hirshfeld surface analysis
Summary
Chalcones are one of the most important classes of flavonoids. Natural and synthetic chalcone derivatives have shown a variety of promising biological activities such as anti-inflammatory, anti-gout, anti-histaminic, anti-oxidant, anti-obesity, anti-protozoal, hypnotic and anti-spasmodic activities (Gomes et al, 2017). Heterocyclic compounds including pyrazolines can be synthesized from chalcone derivatives. Many compounds containing pyrazolines show different biological activities and are known to act as anticancer (Johnson et al, 2007; Gomha et al, 2017), antimicrobial (Patel et al, 2016), antitubercular (Taj et al, 2011), anti-inflammatory (Malhotra et al, 2010), anticonvulsant (Siddiqui et al, 2009), antiamoebic (Bhat et al, 2009), antioxidant (Srinivasan et al, 2007), antiviral (Gomha et al, 2016), antibacterial (Kumar et al, 2008) and antinociceptive (Kaplancikli et al, 2009) agents. Pyrazoline derivatives have been synthesized by condensation of chalcones with hydrazine derivatives using conventional synthesis (Shahare et al, 2009; Sridhar et al, 2012) and microwave-assisted synthesis (Kumar et al, 2008; Patel et al, 2016). The molecular and crystal structure of the title compound, 2, are presented together with a Hirshfeld surface analysis and non-covalent interaction plots
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
