Abstract
Fifteen new pyrazole-4-carboxylic oxime ester derivatives were synthesized from benzaldehyde oxime and 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride conveniently. These pyrazole-4-carboxylic oxime ester structures were confirmed by 1H NMR and HRMS. The compound 5f was further confirmed by X-ray diffraction. They crystallized in the monoclinic system, space group C2/c, Z = 8. The fungicidal activity results indicated that some of these compounds possessed good activity against S. sclerotiorum, B. cinerea, R. solani, P. oryae and P. piricola at 50 ppm. Furthermore, the structure-activity relationship was studied by molecular docking simulation.
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