Synthesis, crystal structure and efficient SOD activity of transition compounds constructed with 5-aminoisophthalic acid ligand

Abstract

Three new superoxide dismutase model compounds: [CoL(H2O)]·2H2O (1), [CdL(H2O)]·H2O (2) and [PbL] (3) were successfully synthesized by the reaction of a transition metal salt and 5-aminoisophthalic acid under hydrothermal conditions (L: 5-aminoisophthalic acid). The three compounds were characterized by elemental analysis, infrared spectroscopy, ultraviolet–visible spectroscopy, PXRD analysis and TG analysis. X-ray single crystal diffraction analysis showed that compounds 2 and 3 were 3D inorganic–organic framework structures while compound 1 was a 2D structure. These simulations contained pores structures with maximum sizes of 4.08–14.67 Å. To further explore the functional properties of these compounds, we firstly analyzed their SOD activity, and the results demonstrated that they have different SOD activities. The IC50 values of the three mimics are much smaller than the international standard for SOD standards, demonstrating that these mimics have superior Reactive Oxygen Species resistance.