Abstract
A new Ru(II)-polypyridyl complex, [Ru(L)(dppz) 2](PF 6) 4 (L = 5,5′-di(1-(trimethylammonio)methyl)-2,2′-dipyridyl cation; dppz = dipyrido[3,2- a:2′,3′- c]phenazine]), has been synthesized and structurally characterized. The binding of this complex with calf thymus DNA (CT-DNA) has been investigated by spectroscopic and viscosity measurement. Results indicate that the complex binds to CT-DNA via an intercalative mode. Moreover, the complex reveals a highly efficient DNA cleavage activity upon irradiation at 365 nm, during which supercoiled pBR322 DNA was converted to nicked DNA.
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