Abstract
A novel eight-coordinated dinuclear Ca(II) complex, [Ca2(L)2(H2O)10]·H2O (L = 4-formylbenzene-1,3-disulfonate-3-pyridinecarboxylic hydrazone) (1), was synthesized by the reaction of 3-pyridinecarboxylic hydrazide, disodium 4-formylbenzene-1,3-disulfonate, and Ca(ClO4)2·4H2O in ethanol-water solution (v:v = 3:1) at 50 °C. Complex 1 was characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and X-ray single crystal diffraction analysis. Dinuclear Ca(II) complex 1 belongs to triclinic, space group P-1 with a = 7.186(3) Å, b = 11.978(5) Å, c = 12.263(5) Å, α = 90.318(5)°, β = 91.922(5)°, γ = 96.797(5)°, V = 1047.5(8) Å3, Z = 1, Dc = 1.685 mg·m−3, μ = 0.572 mm−1, F(000) = 552, and final R1 = 0.0308, ωR2 = 0.0770. Dinuclear Ca(II) molecules form a 1D chained structure by π–π stacking interaction. The 1D chains form a 3D framework structure by the π–π stacking interaction and hydrogen bonds. The in vitro cytotoxic activity activity of 1 against HL-60 and MLTC-1 was also investigated.
Highlights
The biological activities of metal complexes have been a hot research topic since cisplatin was used as an antitumor drug
The dinuclear Ca(II) complex conforms to the formula
The dinuclear Ca(II) complex are soluble in DMF, DMSO, H2 O, and CH3 OH, insoluble in THF, The dinuclear Ca(II) complex are soluble in DMF, DMSO, H2O, and CH3OH, insoluble in THF, CHCl3, and benzene
Summary
The biological activities of metal complexes have been a hot research topic since cisplatin was used as an antitumor drug. Many metal complexes with transition metals as center ions show excellent antibacterial and antitumor activities, such as Cu(II) [1,2,3], Zn(II) [4,5,6], Mn(II) [7,8,9], Ni(II) [10,11,12], Ag(I) [13,14,15], and so on. The design and synthesis of novel hydrazone compounds and their transition metal complexes have received more attention. Compared with transition metal complexes, the studies on the antibacterial and antitumor activities of Ca(II) complexes are rare. The in vitro cytotoxic activity of 1 against HL-60 and MLTC-1 was investigated
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