Abstract
A series of Cu(II) coordination compounds with benzimidazole-derived bidentate chelating ligands have been prepared and characterized by X-ray crystallography. The 2-(4,5-dihydro-1 H-imidazol-2-yl)-1 H-benzimidazole CuCl 2 complex 8 showed very potent superoxide dismutase (Cu,Zn-SOD) activity in vitro with IC 50 of 0.09 μM, comparable to those described in the literature for best low molecular weight CuZnSOD mimics. Cytotoxicity studies with seven different human tumor cell lines in vitro showed that the most active 2-(4,5-dihydro-1 H-imidazol-2-yl)-5-nitro-1 H-benzimidazole CuCl 2 complex 10 inhibited the growth of cancer cells with IC 50 between 4.76 and 10.84 μM.
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