Abstract
A series of half‐sandwich ruthenium(II) arene complexes [(η6‐p‐cymene)RuII(R‐BzTSC)Cl]Cl 1, 2, 3 (BzTSC = benzaldehyde thiosemicarbazone and R = H, CH3 and C6H5) have been synthesized and characterized by IR, 1H NMR, UV‐visible, electrospray ionization mass spectrometry and elemental analysis. The single‐crystal structures of 1 and 3 have been determined. The molecular orbitals and electronic absorption spectra of the compounds have been calculated using the DFT and TDDFT methods. The in vitro antiproliferative activities of these complexes have been evaluated against four human cancer cell lines (CNE, H292, SKBR3 and Hey1‐B), and 3 is proved to be the most efficient inhibitor, with IC50 values of 20, 31, 10 and 34 μm, respectively. Copyright © 2013 John Wiley & Sons, Ltd.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
