Synthesis, chemical and biological properties of &{Pt[S(CH 2) 3Cl] 2} 6 and Pt[C 6H 3( oCH 2CH  CH 2)( p-CH 3)] 2

Abstract

PtCl 4 2− with the ligand HS(CH 2) 3Cl affords a linear polymer which is converted into the hexamer title compound by heating in xylene in the presence of a small amount of dimethylsulphoxide. The hexamer undergoes Cl substitution upon reaction with NaBr or NaI. From the reaction of PtCl 2 with the Grignard reagent of o-allyl- p-methyl-chlorobenzene is obtained the monomer complex Pt[C 6H 3(CH 2CH  CH 2- o) (CH 3 p)] 2. The biological properties of the complexes as inhibitors of DNA, RNA and protein synthesis has been evaluated.