Synthesis, charecterization and antibiological activities of N'-(2-Hydroxyphenyl)-N'- (4-Methylpiperazin-1-YL) Furan-2-Carbohydrazide

Abstract

Present study deals with synthesis of novel Mannich bases from N'-(2-HYDROXY PHENYL)-N'-(4-METHYLPIPERAZIN-1-YL) FURAN-2-CARBOHYDRAZIDE instead of formaldehyde, other aliphatic or aromatic aldehydes or ketones can be employed. The amine used may be ammonia or 1o or 2o aliphatic amine. Mostly diethyl amine is preferred to use. The newly synthesized compounds were characterized by elemental analysis for IR, electronic absorption spectra, TLC. All the synthesized compounds were tested for their antibacterial activities against Gram positive and Gram negative bacteria, antimicrobial activities and antifungal activities